Publications

Peer Reviewed Publications

2022

Pamenter ME (2022). Adaptations to a hypoxic lifestyle in naked mole-rats. Journal of Experimental Biology. In press.
Eaton L and Pamenter ME (2022). What do do with low O2: redox adaptations in vertebrates native to hypoxic environments. Comparative Biochemistry and Physiology A. In press.
Peng Y-J, Nanduri J, Wang N, Khan SA, Pamenter ME and Prabhakar NR (2022). Carotid body responses to O2 and CO2 in hypoxia-tolerant naked mole-rats. Acta Physiologica. In press.
Jorge PF, Goodwin ML, Renes MH, Nijsten MW and Pamenter ME (2022). Low cancer incidence in naked mole-rats may be related to their inability to express the Warburg effect. Frontiers in Physiology. In press.
Eaton L, Wang T, Roy M, and Pamenter ME (2022). Naked mole-rat cortex maintains reactive oxygen species homeostasis during in vitro hypoxia or ischemia and reperfusion. Current Neuropharmacology. In press.
Huynh K, Sabir S, Cheng H and Pamenter ME (2022). Acute pH alterations do not impact cardiac mitochondrial respiration in naked mole-rats or mice. Comparative Biochemistry and Physiology A. In press.
Huynh K and Pamenter ME (2022). Lactate inhibits naked mole-rat cardiac mitochondrial respiration. Journal of Comparative Physiology B. In press.
D’Alessio S, Cheng H, Eaton L, Kraev I, Pamenter ME and Lange S (2022). Acute hypoxia alters extracellular vesicle signatures and the brain citrusllinome of naked mole-rats (Heterocephalus glaber). International Journal of Molecular Sciences. In press.
 Thoral E, Farhat E, Roussel D, Cheng H, Guillard L, Pamenter ME, Weber J-M and Teulier L (2022). Different patterns of chronic hypoxia lead to hierarchical adaptative mechanisms in goldfish metabolism. Journal of Experimental Biology. 225(1):243194.
 Cheng H, Qin Y, Dhillon R, Dowell J, Denu JM and Pamenter ME (2022). Metabolomic analysis of carbohydrate and amino acid changes induced by hypoxia in naked mole-rat brain and liver Metabolites. In press.
 Buffenstein R, Amorosa V, Andziak B, Avdieiev S, Azpurua J, Barker A, Bennet N, Brieno-Enriquez M, Bronner G, Coen C, Delaney M, Dengler-Crish CM, Edrey YH, Faulkes CG, Frankel D, Friedlander G, Gibney PA, Gorbunova V, Hine X, Holmes MM, Jarvis JUM, Kawamura Y, Kutsukake N, Kenyon C, Khaled WT, Kikusui T, Kissil J, Lagestee S, Larson J, Lauer A, Lavrenchenko LA, Lee A, Levitt JB, Lewin GR, Lewis Hardell KN, Lin TD, Mason MJ, McCloskey D, McMahon M, Miura K, Mogi K, Narayan V, O’Connor TP, Okanoya K, O’Riain MJ, Park TJ, Place NJ, Podshivalova K, Pamenter ME, Pyott SJ, Reznick J, Ruby JG, Salmon AB, Santos-Sacchi J, Sarko DK, Seluanov A, Shepard A, Smith M, Storey KB, Tian X, Vice EN, Viltard M, Watarai A, Wywial E, Yamakawa M, Zemlemerova ED, Zions E and St. John Smith E. (2022). The naked truth: busting myths of naked mole-rat biology. Biology Reviews. 97(1):115-140.
 Pamenter ME and Cheng H (2022). Supermole-rat to the rescue: does the naked mole-rat offer a panacea for all that ails us? Comparative Biochemistry and Physiology A. In press.

2021

Cheng H, Sebaa R, Malholtra N, Lacoste B, El Hankouri Z, Kirby A, Bennett NC, van Jaarseld B, Hart DW, Tattersall GJ, Harper ME and Pamenter ME (2021). Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1. Nature Communications. 12(1):6801.
 Cheng H and Pamenter ME (2021). Naked mole-rat brain mitochondria tolerate in vitro ischemia. Journal of Physiology. 599(20):4671-4685.
 Cheng H, Munro D and Pamenter ME (2021). Dynamic calculation of ATP/O ratios measured using Magnesium Green (MgGr)™. MethodsX. 2021.101520.
 Farhat E, Devereaux MEM, Cheng H, Weber J-M and Pamenter ME (2021). Na+/K+-ATPase activity is regionally regulated by acute hypoxia in naked mole-rat brain. Neuroscience Letters. 764:136244.
 Devereaux MEM, Campbell KL, Munro D, Blier PU and Pamenter ME (2021). Burrowing star-nosed moles (Condylura cristata) are not hypoxia-tolerant. Journal of Experimental Biology. 224(19):jeb242972.
 Hadj-Moussa H, Chiasson S, Cheng H, Eaton L, Storey KB and Pamenter ME (2021). MicroRNA-mediated inhibition of AMPK coordinates tissue-specific down regulation of skeletal muscle metabolism in hypoxic naked mole-rats. Journal of Experimental Biology. 224(15):jeb242968.
 Cheng H, Munro D, Huynh K and Pamenter ME (2021). Naked mole-rat skeletal muscle mitochondria exhibit minimal functional plasticity following acute or chronic hypoxia. Comparative Biochemistry and Physiology B. 255:110596.
 Little AG, Pamenter ME, Sitaraman D, Templeman NM, Willmore WG, Hedrick MS and Moyes CD (2021). Utilizing Comparative Models in Biomedical Research. Comparative Biochemistry and Physiology A&B. Invited Editorial. 256:110938.
 Farhat E, Cheng H, Romestaing C, Pamenter ME and Weber JM (2021). Goldfish response to chronic hypoxia: Mitochondrial respiration, fuel preference and energy metabolism. Metabolites. 11(3):187.
 Hadj-Moussa H, Pamenter ME, and Storey KB (2021). Naked mole-rat brains use microRNA to coordinate hypometabolic fuels and neuroprotective defenses during hypoxia. Journal of Cellular Physiology. 236(7):5080-5097.

2020

Ivy CM, Sprenger RJ, Bennett NC, van Jaarsveld B, Hart J, Kirby AM, Yaghoubi D, Storey KB and Pamenter ME (2020). The hypoxia tolerance of 8 related African mole-rat species rivals that of naked mole-rats, despite divergent ventilatory and metabolic strategies in severe hypoxia. Acta Physiologica. 228(4):e13436.
 Wang TH, Eaton L and Pamenter ME (2020). Nitric oxide homeostasis is maintained during acute in vitro hypoxia and following reoxygenation in naked mole-rat but not mouse cortical neurons. Comparative Biochemistry and Physiology A. 250:110792).
 Clayson MS, Devereaux MEM and Pamenter ME (2020). Neurokinin-1 receptor activation is sufficient to restore the hypercapnic ventilatory response in the Substance P-deficient naked mole-rat. American Journal of Physiology – Regulatory and Comparative Physiology. 318(4):R712-R721.
 Pamenter ME, Hall JE, Tannabe Y and Simonson TS (2020). Cross-species insights into genomic adaptations to life in hypoxia. Frontiers in Genetics. 11:743.
 Farhat E, Devereaux MEM, Pamenter ME and Weber JM (2020). Naked mole-rats suppress energy metabolism and remodel membranes in chronic hypoxia. American Journal of Physiology – Regulatory and Comparative Physiology. 319(2):R148-155.
 Devereaux MEM and Pamenter ME (2020). Fossorial Giant Zambian mole-rats have blunted ventilatory responses to environmental hypoxia and hypercapnia. Comparative Biochemistry and Physiology A. 243:110672.
 Logan SM, Szereszewski KE, Bennett NC, Hart DW, van Jaarsveld B, Pamenter ME and Storey KB (2020). Hypoxia induces divergent activation of cellular signaling pathways in the brains of six African mole-rat species. Journal of Experimental Biology.
 Lau GY, Milsom WK, Richards JG and Pamenter ME (2020). Heart mitochondria from naked mole-rats (Heterocephalus glaber) are more coupled, but similarly susceptible to anoxia-reoxygenation stress than in laboratory mice (Mus musculus). Comparative Biochemistry and Physiology B. 240:110375.
 Al-attar R, Childers CL, Nguyen VC, Pamenter ME and Storey KB (2020). Differential protein phosphorylation is responsible for hypoxia-induced regulation of the Akt/mTOR pathway in naked mole rats. Comparative Biochemistry and Physiology A. 242:110653.

2019

Munro D and Pamenter ME (2019). Comparative studies of mitochondrial ROS in animal longevity: pitfalls and possibilities Aging Cell. 18(5):e13009.
 Nguyen VC, Deck CA and Pamenter ME (2019). Naked mole rats reduce the expression of ATP-dependent but not ATP-independent heat shock proteins in acute hypoxia. Journal of Experimental Biology. 222(22):jeb211243.
 Pamenter ME Usyal-Onganer P, Hyunh K, Kraev I and Sigrun S (2019). Post-translational Deimination of Immunological and Metabolic Protein Markers in Plasma and Extracellular Vesicles of Naked Mole-rat (Heterocephalus glaber). International Journal of Molecular Science. 20(21):E7378.
 Hawkins LJ, Hadj-Moussa H, Nguyen VC, Pamenter ME and Storey KB (2019). Naked mole rats activate neuroprotective proteins during hypoxia. Journal of Experimental Zoology. 331(10):571-576.
 Pamenter ME and Munro D (2019). Longevity or hypoxia: who’s driving? Aging. 11(16):5864-5865.
 Vandewint A, Zhu-Palowsky A, Kirby A, Tattersall GJ and Pamenter ME (2019). Evaporative cooling and vasodilation mediate thermoregulation in naked mole rats during normoxia but not hypoxia. Journal of Thermal Biology. 84:228-235.
 Pamenter ME, Dzal YA, Thompson A and Milsom WK (2019). Do naked mole rats accumulate metabolic acidosis or an oxygen debt in severe hypoxia? Journal of Experimental Biology. 222(3):jeb191197.
 Bosma KJ, Syring KE, Oeser JK, Benninger RKP, Pamenter ME and O’Brien RM (2019). Evidence That Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species. Journal of Molecular Evolution. 87(4-6):147-151.
 Dzal YA, Seow A, Borecky LG, Chung D, Gill SK, Milsom WK and Pamenter ME (2019). Glutamatergic receptors modulate normoxic but not hypoxic ventilation and metabolism in naked mole rats. Frontiers in Physiology. 10:106.
 Zhang S and Pamenter ME (2019). Fossorial Damaraland mole rats do not exhibit a blunted hypercapnic ventilatory response. Biology Letters. 15(3):20190006.
 Zhang S and Pamenter ME (2019). Ventilatory, metabolic, and thermoregulatory responses of Damaraland mole rats to acute and chronic hypoxia. Journal of Comparative Physiology B. 189(2)319-334.
 Munro D, Baldy C, Pamenter ME, and Treberg JR (2019). The exceptional longevity of the naked mole-rat may be explained by exceptional mitochondrial antioxidant defenses. Aging Cell. 18(3):e12916.

2018

Pamenter ME, Lau GY, Richards JG and Milsom Wk (2018). Naked mole rat brain mitochondria electron transport system flux and H+ leak are reduced during acute hypoxia. Journal of Experimental Biology. 222(4):jeb171397.
 Pamenter ME, Lau GY and Richards JG (2018). Effects of cold on brain mitochondrial function . PLoS One. 13(12):e0208453.
 Branigan T Elkhalifa S and Pamenter ME (2018). Behavioural Responses to Environmental Hypercapnia in Two Eusocial Species of African Mole Rats. Journal of Comparative Physiology A. 204(9-10):811-819.
 Kirby AM Fairman GD and Pamenter ME (2018). Atypical behavioural, metabolic, and thermoregulatory responses to hypoxia in the naked mole rat (Heterocephalus glaber). Journal of Zoology. 305:106-115.
 Buck LT and Pamenter ME (2018). The Hypoxia-Tolerant Vertebrate Brain: Arresting Synaptic Activity. Comparative Biochemistry and Physiology B. Invited contribution, special issues: Tribute to Peter W Hochachka. 224:61-70.
 Houlahan CR, Kirby AM, Dzal YA, Fairman GD and Pamenter ME (2018). Divergent behavioural responses to acute hypoxia between individuals and groups of naked mole rats . Comparative Biochemistry and Physiology B. Invited contribution, special issues: Tribute to Peter W Hochachka. 224:38-44.

2017

Ilacqua AN, Kirby AM, and Pamenter ME (2017). Behavioural responses of naked mole rats to acute hypoxia and anoxia. Biology letters. 13(12):20170545.

2016

Chung D, Dzal YA, Seow A, Milsom WK and Pamenter ME (2016). Naked mole rats exhibit metabolic but not ventilatory plasticity following chronic sustained hypoxia. Proceedings of the Royal Society B. 283(1827):20162016.
 Pamenter ME and Powell FL (2016). Time domains of the hypoxic ventilatory response and their molecular basis. Comprehensive Physiology. 6(3):1345-1385.
 Pamenter ME (2016). Comparative insights into mitochondrial adaptations to anoxia in brain. Neural Regeneration Research. 11(5):723-724.
 Pamenter ME, Gomez CR, Richards JG and Milsom WK (2016). Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biology Letters. 12:20150797.

2015

Hogg DW, Pamenter ME, Dukoff DJ and Buck LT (2015). Decreases in mitochondrial reactive oxygen species initiate GABAA receptor-mediated electrical suppression in anoxia-tolerant turtle neurons. Journal of Physiology (London). 593(10):2311-2326.
 Dzal YA, Jenkin SE, Lague SL, Reichert MN, York JM and Pamenter ME, (2015). From chemosensory cell to life history: how oxygen has influenced the evolution of vertebrate physiology. Comparative Biochemistry and Physiology A. Invited contribution, special issue: Tribute to William Milsom. 186:4-26.
 Pamenter ME, Go, A, Fu Z and Powell FL (2015). Ventilatory acclimatization to hypoxia is not mediated by neuronal nitric oxide synthase in the NTS of rat. Journal of Applied Physiology. 118(6):750-759.
 Pamenter ME, Dzal Y and Milsom WK (2015). Adenosine receptors inhibit the hypoxic ventilatory response but not the hypoxic metabolic response in the naked mole rat during acute hypoxia. Proceedings of the Royal Society B. 282(1800):20141722.
 Pamenter ME, and Haddad GG (2015). High-throughput cell death assays. Methods in Molecular Biology. Invited contribution. 1254:153-163.

2014

Pamenter ME, Nguyen J, Carr JA and Powell FL (2014). The effect of combined glutamate receptor blockade in the NTS on the hypoxic ventilatory responses in awake rats differs from the effect of individual glutamate receptor blockade. Physiological Reports. 2(7):e12092.
 Pamenter ME, and Haddad GG (2014). Do BK channels mediate glioma hypoxia-tolerance? Channels. Invited contribution. 8(3):1-2.
 Pamenter ME, Go A, Fu Z, Carr JA, Reid SG and Powell FL (2014). Glutamate receptors in the nucleus tractus solitarii mediate ventilatory acclimatization to hypoxia in rat. Journal of Physiology (London). 592(8):1839-1856.
 Pamenter ME, (2014). Mitochondria: A multimodal hub of hypoxia-tolerance. Canadian Journal of Zoology. Invited review, special issue: Animal Mitochondria. 92:569-589.
 Gu XQ*, Pamenter ME* Siemen D*, Sun X and Haddad GG (2014). O2-sensitive BK channels are not O2-sensitive in hypoxia-tolerant human glioma cells. Glia. 62(4):504-13.

2013

Pamenter ME, and Powell FL (2013). Invited review: Signaling mechanisms of long-term facilitation of breathing with intermittent hypoxia. F1000 Reports. 5:23.
 Pamenter ME, Perkins GA, Gu XQ, Ellisman MH and Haddad GG (2013). DIDS (4,4’-diisothiocyano-2,2’-stilbenedisulfonic acid) induces apoptotic cell death in cultured hippocampal neurons and is not protective against ischemic stress. PLoS One. 8(4):e60804.

2012

Pamenter ME, Perkins GA, McGinness AK, Gu XQ, Ellisman MH and Haddad GG (2012). Autophagy and apoptosis are induced in neurons and astrocytes treated with an in vitro mimic of the ischemic penumbra. PLoS One. 7(12):e51469.
 Pamenter ME, Hogg DW, Gu XQ, Buck LT and Haddad GG (2012). Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra. Journal of Cerebral Blood Flow and Metabolism. 32(11)2033-2043.
 Pamenter ME, Ryu J, Hua ST, Perkins GA, Mendiola VL, Gu XQ, Ellisman MH and Haddad GG (2012). DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release. PLoS One. 7(8):e43995.
 Buck LT, Hogg DW, Rodgers-Garlick C and Pamenter ME, (2012). Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex. Advances in Experimental Medicine and Biology. 758:71-79.
 Pamenter ME, Ali SS, Tang Q, Finley JC, Gu XQ, Dugan LL and Haddad GG (2012). An in vitro ischemic penumbral mimic perfusate increases NADPH oxidase-mediated superoxide production in cultured hippocampal neurons. Brain Research. 1452:165-172.
 Mittal M, Gu XQ, Pak O, Pamenter ME, Haag D, Fuchs DB, Schermuly RT, Ghofrani HA, Brandes RP, Seeger W, Grimminger F, Haddad GG and Weissmann N (2012). Hypoxia induces Kv channel current inhibition by increased NAPDH oxidase-derived reactive oxygen species. Free Radicals in Biology and Medicine. 52(6):1033-1042.

2011

Wilkie MP, Pamenter ME, Duquette S, Dhiyebi H, Sangha N, Skelton G, Smith MD and Buck LT (2011). The relationship between NMDA receptor function and the high ammonia tolerance of anoxia-tolerant goldfish (Carassius auratus Linnaeus). Journal of Experimental Biology. 214:4107-4120.
 Pamenter ME, Hogg DW, Ormond J, Shin DS, Woodin MA and Buck LT (2011). Endogenous GABA(A) and GABA(B) receptor-mediated electrical suppression is critical to neuronal anoxia tolerance. Proceedings of the National Academy of Sciences (USA). 108(27):11274-11279.

2008

Pamenter ME, and Buck LT (2008). delta-Opioid receptor antagonism induces NMDA receptor-dependent excitotoxicity in anoxic turtle cortex. Journal of Experimental Biology. 211:3512-3517.
 Wilkie MP, Pamenter ME, Alkabie S, Carapic D, Shin DS and Buck LT (2008). Evidence of anoxia-induced channel arrest in the brain of the goldfish (Carassius auratus). Comparative Biochemistry and Physiology C. 148(4):355-362.
 Pamenter ME, and Buck LT (2008). Neuronal membrane potential is mildly depolarized in the anoxic turtle cortex. Comparative Biochemistry and Physiology A. 150(4):410-414.
 Pamenter ME, Hogg DW and Buck LT (2008). Endogenous reductions in N-methyl-d-aspartate receptor activity inhibit nitric oxide production in the anoxic freshwater turtle cortex. FEBS Letters. 582(12):1738-1742.
 Pamenter ME, Shin DS and Buck LT (2008). Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons. Brain Research. 1213:27-34.
 Pamenter ME, Shin DS, Cooray M and Buck LT (2008). Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle. Journal of Physiology (London). 586(4):1043-1058.
 Pamenter ME, Shin DS and Buck LT (2008). AMPA receptors undergo channel arrest in the anoxic turtle cortex. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 294(2):R606-R613.

2007

Pamenter ME, Richards MD and Buck LT (2007). Anoxia-induced changes in reactive oxygen species and cyclic nucleotides in the painted turtle. Journal of Comparative Physiology B. 177(4):473-481.

2006

Walsh PJ, Veauvy CM, McDonald MD, Pamenter ME, Buck LT and Wilkie MP (2006). Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy. Comparative Biochemistry and Physiology A. 147(2):332-343.
 Buck LT and Pamenter ME, (2006). Adaptive responses of vertebrate neurons to anoxia – matching supply to demand. Respiratory Physiology and Neurobiology. 154(1-2):226-240.

2005

Shin DS, Wilkie MP, Pamenter ME, and Buck LT (2005). Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex. Comparative Biochemistry and Physiology A. 142(1):50-57.

Book Chapters

paper iconPamenter ME (2016). Delta-opioid receptors and glutamatergic toxicity. Neural function of the delta-opioid receptor. New York, USA: Springer Publishing (Y. Xia, editor).

paper iconPamenter ME and Baldy C (2017). Chronic intermittent hypoxia contributes to sleep-disordered breathing in infants and adults. Berlin, GER: Avid Science (S. Ravini, editor).
paper iconBorecky LG and Pamenter ME (2017). Oxygen sensing and transcriptional regulation of adaptive responses to hypoxia. New York, USA: Nova Science (MJ. Cosgrove, editor).
paper iconPamenter ME (2015). High-throughput cell death assays. Neuronal Cell Death – Methods and Protocols. New York, USA: Springer Publishing (J. Walker, editor).
paper iconPamenter ME and Ali SS (2014). Registering superoxide production in live neuronal culture by EPR. Free Radicals: The Role of Antioxidants and Pro-oxidants in Cancer Development. New York, USA: Nova Science (W Stone, editor).
paper iconBuck LT, Hogg DW, Rodgers C and Pamenter ME (2012). The Painted Turtle as a model of natural anoxia tolerance: role of the neurotransmitter GABA. Turtles: Anatomy, Ecology and Conservation. New York, USA: Nova Science (MJ Cosgrove, SA Roe, editors).
paper iconBuck LT, Hogg DW, Rodgers-Garlick C and Pamenter ME (2011). Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex. Arterial Chemoreception: From Molecules to Systems. New York, USA: Springer Publishing (N. Gotsiridze-Columbus, editor)